📄 Category

hiv aids

61 papers

HIV/AIDS research remains a critical frontier in global health, focusing on everything from understanding how the virus interacts with the human immune system to developing new treatments and vaccines. This field is constantly evolving, with scientists working tirelessly to improve patient outcomes and move closer to a functional cure. Because these discoveries happen rapidly, staying updated with the latest findings is essential for both experts and the public.

At Gist.Science, we bridge the gap between complex research and clear understanding by processing every new preprint in this category directly from medRxiv. We transform these dense scientific documents into both plain-language explanations and detailed technical summaries, ensuring that the latest insights into HIV and AIDS are accessible to everyone. Below are the most recent papers we have analyzed, offering a fresh look at the ongoing fight against the virus.

📄 hiv aids

Pre-migratory, Migratory and Post-migratory Factors Associated with Risky Sexual Behaviour among Women Informal Cross-Border Traders at the COMESA Market, Lusaka, Zambia

This study of 499 women informal cross-border traders in Lusaka, Zambia, reveals that risky sexual behavior is significantly influenced by a continuum of pre-migratory, migratory, and post-migratory factors, including reliance on family capital, specific border routes like Katima Mulilo, and accommodation conditions, underscoring the need for targeted interventions focusing on financial independence and safe living environments.

Mwale, S., Lemba, M., Phiri, M.2026-07-25
📄 hiv aids

Time to PrEP Disengagement and Associated Factors Among Adolescents and Young Adults from Key and Priority Populations in Uganda. A survival Analysis

This retrospective survival analysis of 3,553 adolescents and young adults in eastern Uganda reveals that PrEP disengagement occurs rapidly within the first year, with retention significantly influenced by relational factors like partner HIV status and marital status, as well as service delivery modality and specific vulnerabilities such as STIs and gender-based violence.

Mwima, S., Walwo, S.2026-07-24
📄 hiv aids

Mortality and associated factors among people living with HIV newly initiated into care at Bamenda Regional Hospital: A Retrospective Cohort Study

This retrospective cohort study of 331 newly initiated HIV patients at Bamenda Regional Hospital found a 7.6% three-year mortality rate significantly associated with male sex, opportunistic diseases, comorbidities, abnormal liver enzymes, and advanced WHO clinical stage, highlighting the need for early diagnosis and integrated management of these risk factors.

Ajamah, F., Zefack, J. T., Mengnjo, L. T., Yongwa, O., Ashu, M. A., Nkengfua, S. F., Mbinyui, H., Ketchaji, A.2026-07-20✓ Author reviewed ⓘ
📄 hiv aids

Development and pilot testing of an empowerment-based intervention for adolescents and young adults living with HIV transitioning to adult HIV care in Uganda

This study developed and pilot-tested the Empowerment and Personal Transformation (EPT) intervention for adolescents and young adults living with HIV in Uganda, finding it to be a highly feasible and acceptable approach that effectively addresses the psychosocial and behavioral challenges associated with transitioning to adult HIV care.

Ashaba, S., Favina, A., Baguma, C., Tushemereirwe, P., Nansera, D., Comfort, A., Perkins, J. M., Maling, S., Zanoni, B. (…)2026-06-29
📄 hiv aids

''Circumstantial Determinants'': An Efficient Approach to Reaching People in Need of HIV Prevention?

This study proposes and validates a "Circumstantial Determinants" approach in Zimbabwe, demonstrating that targeting HIV prevention services based on specific social circumstances and settings rather than self-reported risk behaviors can significantly improve the reach and efficiency of identifying priority populations for intervention.

Bagnay, S. H., Gregson, S., Skovdal, M., Maswera, R., Moorhouse, L. R., Ncube, G., Tsenesa, B., Mandizvidza, P., Pickles (…)2026-06-22
📄 hiv aids

Enhanced HIV-1 Control After Antibody Therapy is Associated with Autologous Antibodies and Reservoir Clearance in the RIO trial

In the RIO trial, participants receiving long-acting broadly neutralizing antibodies (3BNC117-LS and 10-1074-LS) experienced enhanced HIV-1 control and a significant reduction in intact proviral reservoirs compared to placebo, with delayed viral rebound correlating to the reservoir's sensitivity to both infused and autologous antibodies.

Fumagalli, M., Kaczynska, A., Allombert, M., Ribeiro, A. L., da Silva, M. O., Hernandez, B. J., Lavine, C., Espinosa, S. (…)2026-06-05
📄 hiv aids

Ultra-low-field MRI as a tool for measuring brain development in at-risk children in LMICS: feasibility, validity and clinical relevance.

This study demonstrates that ultra-low-field (64mT) MRI is a feasible and valid, scalable alternative to high-field (3T) MRI for measuring brain volumes and assessing early language development in HIV-exposed and unexposed children in low- and middle-income countries.

Bradford, L. E., Ringshaw, J. E., Malaba, T. R., Bourke, N. J., Wedderburn, C. J., Williams, S. C., Deoni, S., Reynolds (…)2026-06-05
📄 hiv aids

Experimental human pneumococcal carriage in adults with HIV in Malawi

This study established a safe and acceptable experimental human pneumococcal carriage model in Malawi, revealing that while virally suppressed people living with HIV are not more susceptible to initial pneumococcal acquisition than HIV-uninfected adults, they exhibit impaired clearance, suggesting that prolonged carriage duration rather than increased susceptibility drives the high pneumococcal carriage rates observed in this population.

Doherty, K., Chirwa, A., Nsomba, E., Nkhoma, V., Galafa, B., Kadzanja, G., Mailboy, M., Mangtani, E., Songolo, S., Lipun (…)2026-05-20
📄 hiv aids

Spectrum and Immunovirological Determinants of Tumours Among People Living with HIV in Uganda: A Retrospective Cohort Study from a Specialised HIV Centre, 2017 to 2026

This retrospective cohort study of 217 people living with HIV in Uganda (2017–2026) reveals that despite high viral suppression rates, malignancies remain predominant and are strongly driven by Kaposi sarcoma and immunovirological factors such as low pre-ART CD4 counts and advanced clinical stage, highlighting the need for improved early screening and immune reconstitution strategies.

Mwaka, J., Sserunjogi, C., Nataliya, J.2026-05-01
📄 hiv aids

Impact of a Phased Transition Model on Advanced HIV Disease Outcomes: A Pre- and Post-Implementation Evaluation Study in Malawi

A pre- and post-implementation evaluation in Malawi demonstrates that transitioning Advanced HIV Disease services from partner-led to Ministry of Health leadership significantly reduced 12-month mortality and sustained retention, despite observed declines in CD4 testing and TB preventive therapy uptake.

Maphosa, T., Machekano, R., Denoeud-Ndam, L., Makonokaya, L., Chilikutali, L., Kalitera, L. U., Matiya, E., Mayi, A., Mu (…)2026-04-17